Abstract: This article builds upon the research, education and project portfolio of the AMS Institute in Amsterdam: an interdisciplinary knowledge institute initiated by TU Delft (Delft University of Technology), MIT (Massachusetts Institute of Technology) Boston and Wageningen UR (Wageningen University and Research). At AMS Institute, metropolitan solutions are responses to the urban challenges of sustainability and quality of life, while bringing the field’s brightest minds together in a balanced way representing the quadruple helix, to create innovations for metropolitan solutions, tested and demonstrated in pilot projects and experiments in the city that will have a positive impact on the life of citizens. In this article both the Living Lab way of working of AMS Institute, the challenges addressed and some of the many projects (solutions) developed at the moment are explained. The outlook is to set up a Sino-Dutch peer-to-peer knowledge exchange and collaboration on highly innovative projects in the urban domain addressing the tremendous challenges that lie ahead of us.